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Blocking the TLR2 pathway inhibits pro-inflammatory cytokines (IL-6, IL-8, and IL-1) and promotes the expression of tight junction proteins, hence restoring the epidermal barrier in AD ( 5 The role of cytokines and adipokines in obesity and AD Analysis of bodies of obese individuals has revealed the presence of metabolic abnormalities, oxidative stress, mitochondrial dysfunction, impaired immune function, and chronic low-grade inflammation ( 5.1 TNF- TNF- is a cytokine that plays a role in inflammation and immune responses ( 5.2 IL-6 Research on the relationship between IL-6 levels in obesity and AD is limited.IL-6 regulates autoimmune and chronic inflammatory diseases

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy